Drug interactions
Isoflurane + Tacrolimus
Severity: Moderate
Isoflurane and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus can prolong the QT interval, and isoflurane may further delay repolarization. Combined use during surgery may raise arrhythmia risk, particularly with hypomagnesemia or hyperkalemia, which are common with tacrolimus.
What this interaction means in plain words
Isoflurane and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check ECG, potassium and magnesium before surgery and correct abnormalities. Monitor the ECG during anesthesia and continue tacrolimus as scheduled unless otherwise indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoflurane
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Isoflurane with Tacrolimus?
MediHelp rates the interaction as moderate. Isoflurane and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus can prolong the QT interval, and isoflurane may further delay repolarization. Combined use during surgery may raise arrhythmia risk, particularly with hypomagnesemia or hyperkalemia, which are common with tacrolimus.
How serious is the interaction between Isoflurane and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG, potassium and magnesium before surgery and correct abnormalities. Monitor the ECG during anesthesia and continue tacrolimus as scheduled unless otherwise indicated.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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