Drug interactions
Isoflurane + Vorinostat
Severity: Moderate
Isoflurane and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorinostat has been associated with QT prolongation, and isoflurane has a similar effect. Combined use may add to the risk of ventricular arrhythmia.
What this interaction means in plain words
Isoflurane and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Vorinostat belongs to Oncology.
Why it happens
Additive QT prolongation through delayed cardiac repolarization.
What to do
Check a baseline ECG and correct electrolytes before anesthesia. Monitor the ECG perioperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoflurane
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Isoflurane with Vorinostat?
MediHelp rates the interaction as moderate. Isoflurane and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorinostat has been associated with QT prolongation, and isoflurane has a similar effect. Combined use may add to the risk of ventricular arrhythmia.
How serious is the interaction between Isoflurane and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and correct electrolytes before anesthesia. Monitor the ECG perioperatively.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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