Drug interactions
Isoniazid + Levamlodipine
Severity: Minor
Isoniazid and Levamlodipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine, including its levo-enantiomer, is metabolized by CYP3A4, and inhibitors can raise its concentrations, leading to hypotension and peripheral edema. Isoniazid's inhibition of this enzyme is modest, so the effect is usually small.
What this interaction means in plain words
Isoniazid and Levamlodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoniazid belongs to Anti Bacterial; Levamlodipine belongs to Cardiovascular.
Why it happens
Isoniazid inhibits CYP3A4, slightly reducing levamlodipine clearance.
What to do
Monitor blood pressure and ankle edema after starting isoniazid. Lower the levamlodipine dose if hypotension or edema develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Other interactions of Levamlodipine
- Dantrolene + Levamlodipine Major
- Amiodarone + Levamlodipine Moderate
- Amobarbital + Levamlodipine Moderate
- Apalutamide + Levamlodipine Moderate
- Aprepitant + Levamlodipine Moderate
- Armodafinil + Levamlodipine Moderate
Frequently asked questions
Can I take Isoniazid with Levamlodipine?
MediHelp rates the interaction as minor. Isoniazid and Levamlodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amlodipine, including its levo-enantiomer, is metabolized by CYP3A4, and inhibitors can raise its concentrations, leading to hypotension and peripheral edema. Isoniazid's inhibition of this enzyme is modest, so the effect is usually small.
How serious is the interaction between Isoniazid and Levamlodipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and ankle edema after starting isoniazid. Lower the levamlodipine dose if hypotension or edema develops.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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