Drug interactions
Isoniazid + Lopinavir
Severity: Minor
Isoniazid and Lopinavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid is a weak CYP3A4 inhibitor and might slightly raise lopinavir levels, but the effect is not clinically significant. Both drugs can cause hepatotoxicity, which is the more relevant concern in HIV and tuberculosis co-treatment.
What this interaction means in plain words
Isoniazid and Lopinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoniazid belongs to Anti Bacterial; Lopinavir belongs to Anti Virals.
Why it happens
Weak CYP3A4 inhibition by isoniazid; additive hepatotoxic potential.
What to do
No dose adjustment is needed. Monitor liver function tests periodically during co-treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Isoniazid with Lopinavir?
MediHelp rates the interaction as minor. Isoniazid and Lopinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid is a weak CYP3A4 inhibitor and might slightly raise lopinavir levels, but the effect is not clinically significant. Both drugs can cause hepatotoxicity, which is the more relevant concern in HIV and tuberculosis co-treatment.
How serious is the interaction between Isoniazid and Lopinavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor liver function tests periodically during co-treatment.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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