Drug interactions
Isoniazid + Methylprednisolone
Severity: Minor
Isoniazid and Methylprednisolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid may modestly raise methylprednisolone exposure, but the evidence for this is weak and inconsistent. Isoniazid is also a variable CYP3A4 inhibitor and inducer, and the clinical importance of any effect is uncertain.
What this interaction means in plain words
Isoniazid and Methylprednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoniazid belongs to Anti Bacterial; Methylprednisolone belongs to Endocrine.
Why it happens
Possible CYP3A4 inhibition by isoniazid reducing methylprednisolone clearance; the effect is not well established.
What to do
No dose change is usually required. Watch for signs of corticosteroid excess such as hyperglycemia and fluid retention during prolonged co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Isoniazid and Methylprednisolone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Methylprednisolone?
MediHelp rates the interaction as minor. Isoniazid and Methylprednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid may modestly raise methylprednisolone exposure, but the evidence for this is weak and inconsistent. Isoniazid is also a variable CYP3A4 inhibitor and inducer, and the clinical importance of any effect is uncertain.
How serious is the interaction between Isoniazid and Methylprednisolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required. Watch for signs of corticosteroid excess such as hyperglycemia and fluid retention during prolonged co-therapy.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
