Drug interactions
Isoniazid + Midostaurin
Severity: Moderate
Isoniazid and Midostaurin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midostaurin and its active metabolites are CYP3A4 substrates, and higher exposure increases nausea, QT effects and other toxicities. Isoniazid may modestly increase exposure and also adds hepatotoxicity risk.
What this interaction means in plain words
Isoniazid and Midostaurin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Midostaurin belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by isoniazid may raise midostaurin exposure.
What to do
Monitor for adverse reactions, especially during the first week of therapy, and check liver tests and ECG. Manage toxicity with midostaurin interruption or dose reduction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Midostaurin
Frequently asked questions
Can I take Isoniazid with Midostaurin?
MediHelp rates the interaction as moderate. Isoniazid and Midostaurin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midostaurin and its active metabolites are CYP3A4 substrates, and higher exposure increases nausea, QT effects and other toxicities. Isoniazid may modestly increase exposure and also adds hepatotoxicity risk.
How serious is the interaction between Isoniazid and Midostaurin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse reactions, especially during the first week of therapy, and check liver tests and ECG. Manage toxicity with midostaurin interruption or dose reduction.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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