Drug interactions
Isoniazid + Omaveloxolone
Severity: Moderate
Isoniazid and Omaveloxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone is metabolized mainly by CYP3A4, and higher exposure can cause transaminase elevation and other adverse effects. Isoniazid may modestly increase levels and adds hepatotoxic potential.
What this interaction means in plain words
Isoniazid and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Omaveloxolone belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by isoniazid may raise omaveloxolone exposure, with overlapping liver effects.
What to do
Monitor ALT, AST and bilirubin regularly. Reduce the omaveloxolone dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Isoniazid with Omaveloxolone?
MediHelp rates the interaction as moderate. Isoniazid and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omaveloxolone is metabolized mainly by CYP3A4, and higher exposure can cause transaminase elevation and other adverse effects. Isoniazid may modestly increase levels and adds hepatotoxic potential.
How serious is the interaction between Isoniazid and Omaveloxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ALT, AST and bilirubin regularly. Reduce the omaveloxolone dose if adverse effects emerge.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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