Drug interactions
Isoniazid + Oxycodone
Severity: Moderate
Isoniazid and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid can inhibit CYP enzymes including CYP3A4 and may increase oxycodone exposure. This may cause greater sedation and respiratory depression.
What this interaction means in plain words
Isoniazid and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Oxycodone belongs to Musculoskeletal.
Why it happens
Isoniazid inhibition of CYP3A4 (and possibly other CYPs) reduces oxycodone clearance.
What to do
Monitor for sedation and slowed breathing when starting isoniazid in patients on oxycodone. Lower the oxycodone dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Oxycodone?
MediHelp rates the interaction as moderate. Isoniazid and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid can inhibit CYP enzymes including CYP3A4 and may increase oxycodone exposure. This may cause greater sedation and respiratory depression.
How serious is the interaction between Isoniazid and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and slowed breathing when starting isoniazid in patients on oxycodone. Lower the oxycodone dose if needed.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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