Drug interactions
Isoniazid + Palbociclib
Severity: Moderate
Isoniazid and Palbociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palbociclib is cleared mainly by CYP3A4, and isoniazid may raise its exposure. This may worsen neutropenia and other adverse effects.
What this interaction means in plain words
Isoniazid and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Palbociclib belongs to Oncology.
Why it happens
Isoniazid inhibits CYP3A4, reducing palbociclib clearance.
What to do
Monitor complete blood counts closely. Reduce the palbociclib dose if significant neutropenia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Palbociclib
Frequently asked questions
Can I take Isoniazid with Palbociclib?
MediHelp rates the interaction as moderate. Isoniazid and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palbociclib is cleared mainly by CYP3A4, and isoniazid may raise its exposure. This may worsen neutropenia and other adverse effects.
How serious is the interaction between Isoniazid and Palbociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely. Reduce the palbociclib dose if significant neutropenia occurs.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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