Drug interactions
Isoniazid + Panobinostat
Severity: Moderate
Isoniazid and Panobinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Panobinostat is partly cleared by CYP3A4, and strong inhibitors increase its exposure, raising the risk of diarrhea, cytopenias and QT prolongation. Isoniazid is a weaker inhibitor, so the increase is probably smaller, although the potential toxicity of panobinostat is significant.
What this interaction means in plain words
Isoniazid and Panobinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Panobinostat belongs to Oncology.
Why it happens
Isoniazid inhibits CYP3A4, reducing panobinostat clearance.
What to do
Monitor the ECG, blood counts and gastrointestinal toxicity closely. Consider reducing the panobinostat dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
Frequently asked questions
Can I take Isoniazid with Panobinostat?
MediHelp rates the interaction as moderate. Isoniazid and Panobinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Panobinostat is partly cleared by CYP3A4, and strong inhibitors increase its exposure, raising the risk of diarrhea, cytopenias and QT prolongation. Isoniazid is a weaker inhibitor, so the increase is probably smaller, although the potential toxicity of panobinostat is significant.
How serious is the interaction between Isoniazid and Panobinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG, blood counts and gastrointestinal toxicity closely. Consider reducing the panobinostat dose if toxicity develops.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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