Drug interactions
Isoniazid + Polatuzumab vedotin
Severity: Moderate
Isoniazid and Polatuzumab vedotin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The MMAE component of polatuzumab vedotin is a CYP3A4 substrate, and strong inhibitors raise MMAE exposure. Isoniazid is only a weak inhibitor, so a significant effect is unlikely. Both drugs can cause peripheral neuropathy and hepatotoxicity.
What this interaction means in plain words
Isoniazid and Polatuzumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Polatuzumab vedotin belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by isoniazid may raise MMAE exposure; additive neurotoxicity and hepatotoxicity.
What to do
Monitor for neuropathy, neutropenia and liver enzyme elevations. Give pyridoxine with isoniazid and adjust polatuzumab according to toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Polatuzumab vedotin
Frequently asked questions
Can I take Isoniazid with Polatuzumab vedotin?
MediHelp rates the interaction as moderate. Isoniazid and Polatuzumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The MMAE component of polatuzumab vedotin is a CYP3A4 substrate, and strong inhibitors raise MMAE exposure. Isoniazid is only a weak inhibitor, so a significant effect is unlikely. Both drugs can cause peripheral neuropathy and hepatotoxicity.
How serious is the interaction between Isoniazid and Polatuzumab vedotin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neuropathy, neutropenia and liver enzyme elevations. Give pyridoxine with isoniazid and adjust polatuzumab according to toxicity.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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