Drug interactions
Apalutamide + Polatuzumab vedotin
Severity: Moderate
Apalutamide and Polatuzumab vedotin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The cytotoxic payload of polatuzumab vedotin, MMAE, is a CYP3A4 substrate. A CYP3A4 inducer such as apalutamide may reduce unconjugated MMAE exposure and possibly efficacy, although the effect is considered modest.
What this interaction means in plain words
Apalutamide and Polatuzumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Polatuzumab vedotin belongs to Oncology.
Why it happens
Apalutamide induces CYP3A4, increasing the clearance of unconjugated MMAE.
What to do
Monitor treatment response. Consider alternatives to apalutamide where practical.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Polatuzumab vedotin
Frequently asked questions
Can I take Apalutamide with Polatuzumab vedotin?
MediHelp rates the interaction as moderate. Apalutamide and Polatuzumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The cytotoxic payload of polatuzumab vedotin, MMAE, is a CYP3A4 substrate. A CYP3A4 inducer such as apalutamide may reduce unconjugated MMAE exposure and possibly efficacy, although the effect is considered modest.
How serious is the interaction between Apalutamide and Polatuzumab vedotin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor treatment response. Consider alternatives to apalutamide where practical.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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