Drug interactions
Enzalutamide + Polatuzumab vedotin
Severity: Moderate
Enzalutamide and Polatuzumab vedotin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The MMAE payload released from polatuzumab vedotin is a CYP3A4 substrate, so a strong inducer like enzalutamide may reduce unconjugated MMAE exposure. This could lessen efficacy, though the conjugate itself is unaffected.
What this interaction means in plain words
Enzalutamide and Polatuzumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Polatuzumab vedotin belongs to Oncology.
Why it happens
CYP3A4 induction by enzalutamide increases clearance of unconjugated MMAE.
What to do
Monitor lymphoma response; consider alternatives to strong inducers if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Polatuzumab vedotin
Frequently asked questions
Can I take Enzalutamide with Polatuzumab vedotin?
MediHelp rates the interaction as moderate. Enzalutamide and Polatuzumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The MMAE payload released from polatuzumab vedotin is a CYP3A4 substrate, so a strong inducer like enzalutamide may reduce unconjugated MMAE exposure. This could lessen efficacy, though the conjugate itself is unaffected.
How serious is the interaction between Enzalutamide and Polatuzumab vedotin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lymphoma response; consider alternatives to strong inducers if feasible.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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