Drug interactions
Carbamazepine + Polatuzumab vedotin
Severity: Moderate
Carbamazepine and Polatuzumab vedotin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine may lower unconjugated MMAE exposure from polatuzumab vedotin, which could reduce efficacy. Clinical significance is uncertain.
What this interaction means in plain words
Carbamazepine and Polatuzumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Polatuzumab vedotin belongs to Oncology.
Why it happens
Carbamazepine induces CYP3A4, which metabolises the cytotoxic payload MMAE.
What to do
Where possible choose a non-inducing anticonvulsant during polatuzumab therapy. Monitor treatment response if carbamazepine cannot be avoided.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Polatuzumab vedotin
- Clarithromycin + Polatuzumab vedotin Major
- Amobarbital + Polatuzumab vedotin Moderate
- Apalutamide + Polatuzumab vedotin Moderate
- Chloramphenicol + Polatuzumab vedotin Moderate
- Enzalutamide + Polatuzumab vedotin Moderate
- Isoniazid + Polatuzumab vedotin Moderate
Frequently asked questions
Can I take Carbamazepine with Polatuzumab vedotin?
MediHelp rates the interaction as moderate. Carbamazepine and Polatuzumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine may lower unconjugated MMAE exposure from polatuzumab vedotin, which could reduce efficacy. Clinical significance is uncertain.
How serious is the interaction between Carbamazepine and Polatuzumab vedotin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible choose a non-inducing anticonvulsant during polatuzumab therapy. Monitor treatment response if carbamazepine cannot be avoided.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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