Drug interactions
Chloramphenicol + Polatuzumab vedotin
Severity: Moderate
Chloramphenicol and Polatuzumab vedotin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The MMAE payload released from polatuzumab vedotin is a CYP3A4 substrate. Chloramphenicol may raise MMAE exposure, increasing neutropenia and peripheral neuropathy risk.
What this interaction means in plain words
Chloramphenicol and Polatuzumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Polatuzumab vedotin belongs to Oncology.
Why it happens
CYP3A4 inhibition by chloramphenicol may reduce MMAE clearance.
What to do
Monitor blood counts and neuropathy symptoms closely. Prefer a non-inhibiting antibiotic when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Polatuzumab vedotin
- Clarithromycin + Polatuzumab vedotin Major
- Amobarbital + Polatuzumab vedotin Moderate
- Apalutamide + Polatuzumab vedotin Moderate
- Carbamazepine + Polatuzumab vedotin Moderate
- Enzalutamide + Polatuzumab vedotin Moderate
- Isoniazid + Polatuzumab vedotin Moderate
Frequently asked questions
Can I take Chloramphenicol with Polatuzumab vedotin?
MediHelp rates the interaction as moderate. Chloramphenicol and Polatuzumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The MMAE payload released from polatuzumab vedotin is a CYP3A4 substrate. Chloramphenicol may raise MMAE exposure, increasing neutropenia and peripheral neuropathy risk.
How serious is the interaction between Chloramphenicol and Polatuzumab vedotin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy symptoms closely. Prefer a non-inhibiting antibiotic when possible.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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