Drug interactions
Isoniazid + Pretomanid
Severity: Major
Isoniazid and Pretomanid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid-containing regimens are associated with hepatotoxicity, and isoniazid is a well-known cause of drug-induced liver injury. Using them together increases the chance of serious liver damage.
What this interaction means in plain words
Isoniazid and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Isoniazid belongs to Anti Bacterial; Pretomanid belongs to Anti Bacterial.
Why it happens
Additive hepatotoxicity of the two agents.
What to do
Avoid combining them outside the labeled regimen. Check liver function at baseline and regularly, and stop the offending agents for significant transaminase elevation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Isoniazid
Other interactions of Pretomanid
Frequently asked questions
Can I take Isoniazid with Pretomanid?
MediHelp rates the interaction as major. Isoniazid and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pretomanid-containing regimens are associated with hepatotoxicity, and isoniazid is a well-known cause of drug-induced liver injury. Using them together increases the chance of serious liver damage.
How serious is the interaction between Isoniazid and Pretomanid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining them outside the labeled regimen. Check liver function at baseline and regularly, and stop the offending agents for significant transaminase elevation.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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