Drug interactions
Isoniazid + Repotrectinib
Severity: Moderate
Isoniazid and Repotrectinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repotrectinib is cleared mainly by CYP3A4, and isoniazid has only weak, variable CYP3A inhibitory activity in vivo. A clinically important rise in repotrectinib exposure is possible but not well documented. The legacy classification overstates the likely magnitude.
What this interaction means in plain words
Isoniazid and Repotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Repotrectinib belongs to Oncology.
Why it happens
Isoniazid may weakly inhibit CYP3A4, modestly reducing repotrectinib clearance.
What to do
Monitor for repotrectinib adverse effects such as dizziness, ataxia, and neurotoxicity. Reduce the dose per labeling if toxicity appears, and consider an alternative if a true strong inhibitor is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Isoniazid and Repotrectinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Isoniazid
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Isoniazid with Repotrectinib?
MediHelp rates the interaction as moderate. Isoniazid and Repotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Repotrectinib is cleared mainly by CYP3A4, and isoniazid has only weak, variable CYP3A inhibitory activity in vivo. A clinically important rise in repotrectinib exposure is possible but not well documented. The legacy classification overstates the likely magnitude.
How serious is the interaction between Isoniazid and Repotrectinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for repotrectinib adverse effects such as dizziness, ataxia, and neurotoxicity. Reduce the dose per labeling if toxicity appears, and consider an alternative if a true strong inhibitor is needed.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
