Drug interactions
Isoniazid + Trimipramine
Severity: Minor
Isoniazid and Trimipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid has weak MAO inhibiting activity and trimipramine is a tricyclic antidepressant with some serotonergic activity. A theoretical additive risk of serotonin toxicity exists, but documented cases are rare.
What this interaction means in plain words
Isoniazid and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoniazid belongs to Anti Bacterial; Trimipramine belongs to Central Nervous System.
Why it happens
Weak MAO inhibition by isoniazid combined with the serotonergic effects of trimipramine.
What to do
Monitor for signs of serotonin toxicity such as tremor, agitation, hyperthermia and clonus, particularly at initiation or dose increases. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Isoniazid and Trimipramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Isoniazid
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Isoniazid with Trimipramine?
MediHelp rates the interaction as minor. Isoniazid and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid has weak MAO inhibiting activity and trimipramine is a tricyclic antidepressant with some serotonergic activity. A theoretical additive risk of serotonin toxicity exists, but documented cases are rare.
How serious is the interaction between Isoniazid and Trimipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity such as tremor, agitation, hyperthermia and clonus, particularly at initiation or dose increases. No routine dose change is needed.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
