Drug interactions
Isoniazid + Upadacitinib
Severity: Minor
Isoniazid and Upadacitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid has weak inhibitory effects on CYP3A4 in some settings, which could modestly raise upadacitinib exposure. The effect is not well characterised and is unlikely to be clinically significant in most patients.
What this interaction means in plain words
Isoniazid and Upadacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoniazid belongs to Anti Bacterial; Upadacitinib belongs to Musculoskeletal.
Why it happens
Possible weak CYP3A4 inhibition by isoniazid reducing upadacitinib clearance; this is not well established.
What to do
No dose change is generally needed; monitor for upadacitinib adverse effects such as infection or cytopenias during the TB treatment course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Bcg vaccine live + Upadacitinib Contraindicated
- Dengue vaccine + Upadacitinib Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Upadacitinib Contraindicated
Frequently asked questions
Can I take Isoniazid with Upadacitinib?
MediHelp rates the interaction as minor. Isoniazid and Upadacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid has weak inhibitory effects on CYP3A4 in some settings, which could modestly raise upadacitinib exposure. The effect is not well characterised and is unlikely to be clinically significant in most patients.
How serious is the interaction between Isoniazid and Upadacitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor for upadacitinib adverse effects such as infection or cytopenias during the TB treatment course.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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