Drug interactions
Isoniazid + Valbenazine
Severity: Minor
Isoniazid and Valbenazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid is a weak-to-moderate CYP3A4 inhibitor and may raise valbenazine and its active metabolite exposure. The effect is generally modest but could increase somnolence, QT effects or other dose-related adverse events.
What this interaction means in plain words
Isoniazid and Valbenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoniazid belongs to Anti Bacterial; Valbenazine belongs to Central Nervous System.
Why it happens
Isoniazid inhibits CYP3A4, which contributes to metabolism of the active valbenazine metabolite.
What to do
No routine dose change is needed; monitor for sedation and QT-related symptoms. Apply the 40 mg daily limit only if a strong CYP3A4 inhibitor is given.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Isoniazid with Valbenazine?
MediHelp rates the interaction as minor. Isoniazid and Valbenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid is a weak-to-moderate CYP3A4 inhibitor and may raise valbenazine and its active metabolite exposure. The effect is generally modest but could increase somnolence, QT effects or other dose-related adverse events.
How serious is the interaction between Isoniazid and Valbenazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for sedation and QT-related symptoms. Apply the 40 mg daily limit only if a strong CYP3A4 inhibitor is given.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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