Drug interactions
Isoproterenol + Maprotiline
Severity: Moderate
Isoproterenol and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic-type antidepressants can enhance the cardiovascular effects of adrenergic agents, and isoproterenol may cause greater tachycardia and arrhythmia in patients taking maprotiline. Because isoproterenol is a direct beta agonist not reliant on neuronal reuptake, the potentiation is likely smaller than with norepinephrine or epinephrine.
What this interaction means in plain words
Isoproterenol and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoproterenol belongs to Respiratory; Maprotiline belongs to Central Nervous System.
Why it happens
Additive adrenergic cardiovascular stimulation and sensitization of adrenergic receptors; the mechanism is not fully established for this agent.
What to do
Use the lowest effective isoproterenol dose and monitor heart rate, blood pressure and ECG continuously.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Isoproterenol
Frequently asked questions
Can I take Isoproterenol with Maprotiline?
MediHelp rates the interaction as moderate. Isoproterenol and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic-type antidepressants can enhance the cardiovascular effects of adrenergic agents, and isoproterenol may cause greater tachycardia and arrhythmia in patients taking maprotiline. Because isoproterenol is a direct beta agonist not reliant on neuronal reuptake, the potentiation is likely smaller than with norepinephrine or epinephrine.
How serious is the interaction between Isoproterenol and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective isoproterenol dose and monitor heart rate, blood pressure and ECG continuously.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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