Drug interactions
Isoproterenol + Nadolol
Severity: Major
Isoproterenol and Nadolol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol is a nonselective beta-blocker that competitively blocks the beta-receptors isoproterenol acts on, reducing its heart rate and bronchodilating effects. This can render isoproterenol ineffective, for example in bradycardia or bronchospasm.
What this interaction means in plain words
Isoproterenol and Nadolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Isoproterenol belongs to Respiratory; Nadolol belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism at beta-1 and beta-2 adrenergic receptors.
What to do
Avoid the combination where possible; if isoproterenol is needed in a patient on nadolol, higher doses may be required with close monitoring of heart rate, blood pressure and airway status.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Isoproterenol
Other interactions of Nadolol
Frequently asked questions
Can I take Isoproterenol with Nadolol?
MediHelp rates the interaction as major. Isoproterenol and Nadolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nadolol is a nonselective beta-blocker that competitively blocks the beta-receptors isoproterenol acts on, reducing its heart rate and bronchodilating effects. This can render isoproterenol ineffective, for example in bradycardia or bronchospasm.
How serious is the interaction between Isoproterenol and Nadolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if isoproterenol is needed in a patient on nadolol, higher doses may be required with close monitoring of heart rate, blood pressure and airway status.
What other medicines interact with Isoproterenol?
MediHelp also lists interactions of Isoproterenol with, for example, Adrenaline-articaine, Bisoprolol, Budesonide-formoterol. The full list is on the Isoproterenol page.
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