Drug interactions
Isoproterenol + Nebivolol
Severity: Major
Isoproterenol and Nebivolol: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nebivolol competitively blocks beta receptors and antagonizes the chronotropic, inotropic and bronchodilating effects of isoproterenol. Isoproterenol may be ineffective, and higher doses may be needed.
What this interaction means in plain words
Isoproterenol and Nebivolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Isoproterenol belongs to Respiratory; Nebivolol belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism at beta-adrenergic receptors.
What to do
Avoid the combination where possible, or monitor heart rate, blood pressure and response closely and expect to need higher isoproterenol doses. Consider alternative chronotropic support if the response is inadequate.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Isoproterenol
Frequently asked questions
Can I take Isoproterenol with Nebivolol?
MediHelp rates the interaction as major. Isoproterenol and Nebivolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nebivolol competitively blocks beta receptors and antagonizes the chronotropic, inotropic and bronchodilating effects of isoproterenol. Isoproterenol may be ineffective, and higher doses may be needed.
How serious is the interaction between Isoproterenol and Nebivolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or monitor heart rate, blood pressure and response closely and expect to need higher isoproterenol doses. Consider alternative chronotropic support if the response is inadequate.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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