Drug interactions
Isoproterenol + Quetiapine
Severity: Moderate
Isoproterenol and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine blocks alpha-1 receptors and can cause orthostatic hypotension, and isoproterenol causes beta-mediated vasodilation and tachycardia. Together they may produce additive hypotension and reflex tachycardia.
What this interaction means in plain words
Isoproterenol and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoproterenol belongs to Respiratory; Quetiapine belongs to Central Nervous System.
Why it happens
Quetiapine alpha-1 blockade combined with isoproterenol beta-2 mediated vasodilation leads to additive hypotension.
What to do
Monitor blood pressure and heart rate continuously during isoproterenol infusion in patients taking quetiapine. Adjust the infusion rate and support blood pressure as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Isoproterenol
Frequently asked questions
Can I take Isoproterenol with Quetiapine?
MediHelp rates the interaction as moderate. Isoproterenol and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine blocks alpha-1 receptors and can cause orthostatic hypotension, and isoproterenol causes beta-mediated vasodilation and tachycardia. Together they may produce additive hypotension and reflex tachycardia.
How serious is the interaction between Isoproterenol and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate continuously during isoproterenol infusion in patients taking quetiapine. Adjust the infusion rate and support blood pressure as needed.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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