Drug interactions
Isoproterenol + Tolcapone
Severity: Moderate
Isoproterenol and Tolcapone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoproterenol is partly metabolized by catechol-O-methyltransferase, and tolcapone inhibits this enzyme. Exposure to isoproterenol may rise, leading to exaggerated tachycardia, arrhythmia and blood pressure changes.
What this interaction means in plain words
Isoproterenol and Tolcapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoproterenol belongs to Respiratory; Tolcapone belongs to Central Nervous System.
Why it happens
Inhibition of COMT by tolcapone reduces O-methylation and clearance of isoproterenol.
What to do
Monitor heart rate, rhythm and blood pressure and titrate isoproterenol to effect using lower doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Isoproterenol and Tolcapone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Isoproterenol
Other interactions of Tolcapone
- Isocarboxazid + Tolcapone Contraindicated
- Phenelzine + Tolcapone Contraindicated
- Tolcapone + Tranylcypromine Contraindicated
- Metoclopramide + Tolcapone Major
- Apomorphine + Tolcapone Moderate
- Asenapine + Tolcapone Moderate
Frequently asked questions
Can I take Isoproterenol with Tolcapone?
MediHelp rates the interaction as moderate. Isoproterenol and Tolcapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoproterenol is partly metabolized by catechol-O-methyltransferase, and tolcapone inhibits this enzyme. Exposure to isoproterenol may rise, leading to exaggerated tachycardia, arrhythmia and blood pressure changes.
How serious is the interaction between Isoproterenol and Tolcapone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and blood pressure and titrate isoproterenol to effect using lower doses.
What other medicines interact with Isoproterenol?
MediHelp also lists interactions of Isoproterenol with, for example, Adrenaline-articaine, Bisoprolol, Budesonide-formoterol. The full list is on the Isoproterenol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
