Drug interactions
Isoproterenol + Ziprasidone
Severity: Moderate
Isoproterenol and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoproterenol can cause tachycardia and arrhythmias and can lower blood pressure through beta-2 vasodilation. Ziprasidone adds QT prolongation and alpha-blocking hypotension, so the combination may raise arrhythmia risk and cause exaggerated hypotension.
What this interaction means in plain words
Isoproterenol and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoproterenol belongs to Respiratory; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive proarrhythmic effects from beta-adrenergic stimulation and QT prolongation, with additive vasodilation and hypotension.
What to do
Monitor ECG and blood pressure during isoproterenol infusion and correct potassium and magnesium beforehand. Reduce or stop isoproterenol if QT prolongation or ventricular arrhythmias develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Isoproterenol
Frequently asked questions
Can I take Isoproterenol with Ziprasidone?
MediHelp rates the interaction as moderate. Isoproterenol and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoproterenol can cause tachycardia and arrhythmias and can lower blood pressure through beta-2 vasodilation. Ziprasidone adds QT prolongation and alpha-blocking hypotension, so the combination may raise arrhythmia risk and cause exaggerated hypotension.
How serious is the interaction between Isoproterenol and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and blood pressure during isoproterenol infusion and correct potassium and magnesium beforehand. Reduce or stop isoproterenol if QT prolongation or ventricular arrhythmias develop.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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