Drug interactions
Isradipine + Melatonin
Severity: Moderate
Isradipine and Melatonin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin has been reported in small studies to raise blood pressure in patients on nifedipine-type calcium channel blockers and to blunt their effect. This could reduce blood pressure control with isradipine.
What this interaction means in plain words
Isradipine and Melatonin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible pharmacodynamic antagonism of dihydropyridine antihypertensive effect; mechanism not well established.
What to do
Monitor blood pressure after melatonin is started or stopped. Adjust the antihypertensive regimen if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Isradipine with Melatonin?
MediHelp rates the interaction as moderate. Isradipine and Melatonin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Melatonin has been reported in small studies to raise blood pressure in patients on nifedipine-type calcium channel blockers and to blunt their effect. This could reduce blood pressure control with isradipine.
How serious is the interaction between Isradipine and Melatonin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after melatonin is started or stopped. Adjust the antihypertensive regimen if control worsens.
What other medicines interact with Melatonin?
MediHelp also lists interactions of Melatonin with, for example, Fluvoxamine, Alfentanil, Belladonna and opium. The full list is on the Melatonin page.
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