Drug interactions
Isradipine + Nevirapine
Severity: Moderate
Isradipine and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may reduce isradipine concentrations and weaken its blood pressure lowering effect. Dihydropyridine calcium channel blockers are CYP3A4 substrates and are sensitive to enzyme inducers.
What this interaction means in plain words
Isradipine and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nevirapine induces intestinal and hepatic CYP3A4, increasing first-pass and systemic clearance of isradipine.
What to do
Monitor blood pressure after starting or stopping nevirapine and titrate isradipine to effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Isradipine with Nevirapine?
MediHelp rates the interaction as moderate. Isradipine and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may reduce isradipine concentrations and weaken its blood pressure lowering effect. Dihydropyridine calcium channel blockers are CYP3A4 substrates and are sensitive to enzyme inducers.
How serious is the interaction between Isradipine and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or stopping nevirapine and titrate isradipine to effect.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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