Drug interactions
Istradefylline + Itraconazole
Severity: Moderate
Istradefylline and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole, a strong CYP3A4 inhibitor, raises istradefylline exposure and increases the risk of dyskinesia and other dopaminergic adverse effects. Istradefylline at higher doses can also weakly raise levels of sensitive CYP3A4 substrates.
What this interaction means in plain words
Istradefylline and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Istradefylline belongs to Central Nervous System; Itraconazole belongs to Anti Fungals.
Why it happens
Itraconazole inhibits CYP3A4-mediated metabolism of istradefylline.
What to do
Limit istradefylline to 20 mg daily during itraconazole therapy and monitor for dyskinesia, hallucinations and somnolence.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Itraconazole?
MediHelp rates the interaction as moderate. Istradefylline and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole, a strong CYP3A4 inhibitor, raises istradefylline exposure and increases the risk of dyskinesia and other dopaminergic adverse effects. Istradefylline at higher doses can also weakly raise levels of sensitive CYP3A4 substrates.
How serious is the interaction between Istradefylline and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit istradefylline to 20 mg daily during itraconazole therapy and monitor for dyskinesia, hallucinations and somnolence.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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