Drug interactions
Istradefylline + Lurasidone
Severity: Moderate
Istradefylline and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at the higher 40 mg daily dose can inhibit CYP3A4 and raise exposure to CYP3A4 substrates, which includes lurasidone. This may increase lurasidone adverse effects such as sedation and extrapyramidal symptoms.
What this interaction means in plain words
Istradefylline and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Istradefylline belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Istradefylline weakly to moderately inhibits CYP3A4 at higher doses, reducing lurasidone clearance.
What to do
Monitor for lurasidone adverse effects and consider a lower lurasidone dose if istradefylline 40 mg daily is used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Lurasidone?
MediHelp rates the interaction as moderate. Istradefylline and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Istradefylline at the higher 40 mg daily dose can inhibit CYP3A4 and raise exposure to CYP3A4 substrates, which includes lurasidone. This may increase lurasidone adverse effects such as sedation and extrapyramidal symptoms.
How serious is the interaction between Istradefylline and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lurasidone adverse effects and consider a lower lurasidone dose if istradefylline 40 mg daily is used.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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