Drug interactions
Istradefylline + Mefloquine
Severity: Moderate
Istradefylline and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at 40 mg daily inhibits CYP3A4 and can raise levels of CYP3A4 substrates such as mefloquine. This may increase mefloquine adverse effects.
What this interaction means in plain words
Istradefylline and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Istradefylline belongs to Central Nervous System; Mefloquine belongs to Anti Parasitic.
Why it happens
Istradefylline inhibits CYP3A4 metabolism of mefloquine.
What to do
Monitor for mefloquine toxicity, especially at the 40 mg istradefylline dose. Consider an alternative antimalarial if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Mefloquine?
MediHelp rates the interaction as moderate. Istradefylline and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Istradefylline at 40 mg daily inhibits CYP3A4 and can raise levels of CYP3A4 substrates such as mefloquine. This may increase mefloquine adverse effects.
How serious is the interaction between Istradefylline and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mefloquine toxicity, especially at the 40 mg istradefylline dose. Consider an alternative antimalarial if adverse effects develop.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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