Drug interactions
Istradefylline + Paliperidone
Severity: Moderate
Istradefylline and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at higher doses inhibits P-glycoprotein and has raised exposure to P-gp substrates. Paliperidone is a P-gp substrate, so its levels and adverse effects may increase.
What this interaction means in plain words
Istradefylline and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Istradefylline belongs to Central Nervous System; Paliperidone belongs to Central Nervous System.
Why it happens
Inhibition of intestinal P-glycoprotein efflux increases paliperidone absorption.
What to do
Monitor for sedation, extrapyramidal symptoms and QT effects, and consider lowering the paliperidone dose if istradefylline 40 mg/day is used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Paliperidone?
MediHelp rates the interaction as moderate. Istradefylline and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Istradefylline at higher doses inhibits P-glycoprotein and has raised exposure to P-gp substrates. Paliperidone is a P-gp substrate, so its levels and adverse effects may increase.
How serious is the interaction between Istradefylline and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, extrapyramidal symptoms and QT effects, and consider lowering the paliperidone dose if istradefylline 40 mg/day is used.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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