Drug interactions
Istradefylline + Ribociclib
Severity: Moderate
Istradefylline and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib may raise istradefylline concentrations by inhibiting CYP3A4. Higher exposure may increase dyskinesia and other adverse effects.
What this interaction means in plain words
Istradefylline and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Istradefylline belongs to Central Nervous System; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4 metabolism of istradefylline.
What to do
Monitor for dyskinesia, dizziness and hallucinations. Limit the istradefylline dose to 20 mg daily when used with a moderate CYP3A4 inhibitor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Ribociclib?
MediHelp rates the interaction as moderate. Istradefylline and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib may raise istradefylline concentrations by inhibiting CYP3A4. Higher exposure may increase dyskinesia and other adverse effects.
How serious is the interaction between Istradefylline and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dyskinesia, dizziness and hallucinations. Limit the istradefylline dose to 20 mg daily when used with a moderate CYP3A4 inhibitor.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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