Drug interactions
Istradefylline + Rimegepant
Severity: Moderate
Istradefylline and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline inhibits P-glycoprotein at higher doses and may modestly increase rimegepant exposure. The clinical consequence is likely limited but could raise adverse effects.
What this interaction means in plain words
Istradefylline and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Istradefylline belongs to Central Nervous System; Rimegepant belongs to Central Nervous System.
Why it happens
Inhibition of intestinal P-glycoprotein efflux of rimegepant.
What to do
Avoid giving a second rimegepant dose within 48 hours and monitor tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rimegepant
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Rimegepant?
MediHelp rates the interaction as moderate. Istradefylline and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Istradefylline inhibits P-glycoprotein at higher doses and may modestly increase rimegepant exposure. The clinical consequence is likely limited but could raise adverse effects.
How serious is the interaction between Istradefylline and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving a second rimegepant dose within 48 hours and monitor tolerability.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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