Drug interactions
Istradefylline + Voriconazole
Severity: Moderate
Istradefylline and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole raises istradefylline exposure, which may worsen dyskinesia and other adverse effects. Istradefylline at higher doses can also increase exposure to CYP3A4 substrates.
What this interaction means in plain words
Istradefylline and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Istradefylline belongs to Central Nervous System; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4 metabolism of istradefylline, and istradefylline at high doses weakly inhibits CYP3A4.
What to do
Limit istradefylline to 20 mg daily with voriconazole and monitor for dyskinesia, hallucinations and voriconazole adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Voriconazole?
MediHelp rates the interaction as moderate. Istradefylline and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole raises istradefylline exposure, which may worsen dyskinesia and other adverse effects. Istradefylline at higher doses can also increase exposure to CYP3A4 substrates.
How serious is the interaction between Istradefylline and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit istradefylline to 20 mg daily with voriconazole and monitor for dyskinesia, hallucinations and voriconazole adverse effects.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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