Drug interactions
Itraconazole + Lofexidine
Severity: Major
Itraconazole and Lofexidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may increase the risk of torsades de pointes. Lofexidine also causes bradycardia and hypotension, which add to the arrhythmic risk.
What this interaction means in plain words
Itraconazole and Lofexidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Itraconazole belongs to Anti Fungals; Lofexidine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation; itraconazole may also modestly raise lofexidine exposure through CYP inhibition.
What to do
Avoid the combination when possible. If it is used, obtain a baseline ECG, correct potassium and magnesium, and monitor QTc, heart rate and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Itraconazole with Lofexidine?
MediHelp rates the interaction as major. Itraconazole and Lofexidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so combined use may increase the risk of torsades de pointes. Lofexidine also causes bradycardia and hypotension, which add to the arrhythmic risk.
How serious is the interaction between Itraconazole and Lofexidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible. If it is used, obtain a baseline ECG, correct potassium and magnesium, and monitor QTc, heart rate and blood pressure.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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