Drug interactions
Itraconazole + Netupitant-palonosetron
Severity: Moderate
Itraconazole and Netupitant-palonosetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole is a strong CYP3A4 inhibitor and can increase netupitant exposure. Netupitant is given as a single dose per cycle, and the label does not require adjustment, but itraconazole itself is also a CYP3A4 substrate affected by netupitant.
What this interaction means in plain words
Itraconazole and Netupitant-palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Netupitant-palonosetron belongs to Gastrointestinal Tract.
Why it happens
Inhibition of CYP3A4-mediated netupitant metabolism, and netupitant may in turn raise itraconazole exposure.
What to do
No netupitant dose adjustment is required. Monitor for adverse effects such as headache, constipation and itraconazole toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Netupitant-palonosetron
- Apomorphine + Netupitant-palonosetron Contraindicated
- Flibanserin + Netupitant-palonosetron Contraindicated
- Apalutamide + Netupitant-palonosetron Major
- Avapritinib + Netupitant-palonosetron Major
- Carbamazepine + Netupitant-palonosetron Major
- Cobimetinib + Netupitant-palonosetron Major
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Netupitant-palonosetron?
MediHelp rates the interaction as moderate. Itraconazole and Netupitant-palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole is a strong CYP3A4 inhibitor and can increase netupitant exposure. Netupitant is given as a single dose per cycle, and the label does not require adjustment, but itraconazole itself is also a CYP3A4 substrate affected by netupitant.
How serious is the interaction between Itraconazole and Netupitant-palonosetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No netupitant dose adjustment is required. Monitor for adverse effects such as headache, constipation and itraconazole toxicity.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
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