Drug interactions
Itraconazole + Norgestrel
Severity: Minor
Itraconazole and Norgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may increase norgestrel exposure through CYP3A4 inhibition. This could increase progestogenic adverse effects, though contraceptive efficacy is not expected to be reduced.
What this interaction means in plain words
Itraconazole and Norgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Itraconazole belongs to Anti Fungals; Norgestrel belongs to Endocrine.
Why it happens
CYP3A4 inhibition reduces the metabolism of norgestrel.
What to do
Counsel on hormone-related adverse effects such as bleeding changes and mood effects. No dose adjustment is typically required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Norgestrel
- Amobarbital + Norgestrel Major
- Apalutamide + Norgestrel Major
- Bosentan + Norgestrel Major
- Carbamazepine + Norgestrel Major
- Efavirenz + Norgestrel Major
- Enzalutamide + Norgestrel Major
Frequently asked questions
Can I take Itraconazole with Norgestrel?
MediHelp rates the interaction as minor. Itraconazole and Norgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Itraconazole may increase norgestrel exposure through CYP3A4 inhibition. This could increase progestogenic adverse effects, though contraceptive efficacy is not expected to be reduced.
How serious is the interaction between Itraconazole and Norgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on hormone-related adverse effects such as bleeding changes and mood effects. No dose adjustment is typically required.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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