Drug interactions
Itraconazole + Palovarotene
Severity: Major
Itraconazole and Palovarotene: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole can increase palovarotene exposure by inhibiting its metabolism. This may amplify retinoid toxicity such as mucocutaneous effects, premature growth plate closure in children and hypervitaminosis A-like effects.
What this interaction means in plain words
Itraconazole and Palovarotene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Itraconazole belongs to Anti Fungals; Palovarotene belongs to Miscellaneous.
Why it happens
Strong CYP3A4 inhibition reduces palovarotene clearance.
What to do
Avoid concurrent use of strong CYP3A4 inhibitors with palovarotene; select a non-interacting antifungal. If unavoidable, monitor closely for retinoid toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Palovarotene
- Acitretin + Palovarotene Contraindicated
- Isotretinoin + Palovarotene Contraindicated
- Amiodarone + Palovarotene Major
- Amobarbital + Palovarotene Major
- Apalutamide + Palovarotene Major
- Aprepitant + Palovarotene Major
Frequently asked questions
Can I take Itraconazole with Palovarotene?
MediHelp rates the interaction as major. Itraconazole and Palovarotene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole can increase palovarotene exposure by inhibiting its metabolism. This may amplify retinoid toxicity such as mucocutaneous effects, premature growth plate closure in children and hypervitaminosis A-like effects.
How serious is the interaction between Itraconazole and Palovarotene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of strong CYP3A4 inhibitors with palovarotene; select a non-interacting antifungal. If unavoidable, monitor closely for retinoid toxicity.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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