Drug interactions
Itraconazole + Pantoprazole
Severity: Moderate
Itraconazole and Pantoprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pantoprazole raises gastric pH, which markedly reduces the absorption of itraconazole capsules and may cause subtherapeutic antifungal levels and treatment failure. The effect is much less with the oral solution or the acidic cola co-administration approach.
What this interaction means in plain words
Itraconazole and Pantoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Pantoprazole belongs to Gastrointestinal Tract.
Why it happens
Higher gastric pH decreases dissolution and absorption of itraconazole capsules, which need an acidic environment.
What to do
Use the oral solution or an SUBA-itraconazole formulation, which are less pH-dependent, or stop the acid suppressant if possible. Monitor itraconazole trough levels and clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Frequently asked questions
Can I take Itraconazole with Pantoprazole?
MediHelp rates the interaction as moderate. Itraconazole and Pantoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pantoprazole raises gastric pH, which markedly reduces the absorption of itraconazole capsules and may cause subtherapeutic antifungal levels and treatment failure. The effect is much less with the oral solution or the acidic cola co-administration approach.
How serious is the interaction between Itraconazole and Pantoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the oral solution or an SUBA-itraconazole formulation, which are less pH-dependent, or stop the acid suppressant if possible. Monitor itraconazole trough levels and clinical response.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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