Drug interactions
Itraconazole + Paroxetine
Severity: Minor
Itraconazole and Paroxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT prolongation, although paroxetine carries a low risk. The additive effect is generally small but could matter in patients with other risk factors.
What this interaction means in plain words
Itraconazole and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Itraconazole belongs to Anti Fungals; Paroxetine belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization; the mechanism is largely theoretical for paroxetine.
What to do
Consider an ECG in patients with additional QT risk factors such as electrolyte disturbance, cardiac disease or other QT-prolonging drugs. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Itraconazole with Paroxetine?
MediHelp rates the interaction as minor. Itraconazole and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs have been associated with QT prolongation, although paroxetine carries a low risk. The additive effect is generally small but could matter in patients with other risk factors.
How serious is the interaction between Itraconazole and Paroxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an ECG in patients with additional QT risk factors such as electrolyte disturbance, cardiac disease or other QT-prolonging drugs. Correct potassium and magnesium abnormalities.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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