Drug interactions
Itraconazole + Prednisolone
Severity: Moderate
Itraconazole and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole is a potent CYP3A4 inhibitor and can raise systemic corticosteroid exposure. Prednisolone is affected less than methylprednisolone or dexamethasone, but increased steroid effects, including Cushingoid features and adrenal suppression, may occur with prolonged use.
What this interaction means in plain words
Itraconazole and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Prednisolone belongs to Endocrine.
Why it happens
Itraconazole inhibits CYP3A4 and P-glycoprotein, reducing the clearance of prednisolone.
What to do
Monitor for signs of corticosteroid excess such as hyperglycemia, fluid retention and hypertension, and reduce the prednisolone dose if they appear. Consider the added risk when treatment is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Prednisolone?
MediHelp rates the interaction as moderate. Itraconazole and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole is a potent CYP3A4 inhibitor and can raise systemic corticosteroid exposure. Prednisolone is affected less than methylprednisolone or dexamethasone, but increased steroid effects, including Cushingoid features and adrenal suppression, may occur with prolonged use.
How serious is the interaction between Itraconazole and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of corticosteroid excess such as hyperglycemia, fluid retention and hypertension, and reduce the prednisolone dose if they appear. Consider the added risk when treatment is prolonged.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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