Drug interactions
Itraconazole + Salbutamol
Severity: Minor
Itraconazole and Salbutamol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT prolongation, and salbutamol can lower potassium, which further raises the risk of torsades de pointes. Itraconazole may also modestly raise salbutamol exposure, although this is generally minor with inhaled doses.
What this interaction means in plain words
Itraconazole and Salbutamol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Itraconazole belongs to Anti Fungals; Salbutamol belongs to Respiratory.
Why it happens
Additive QT prolongation, beta-2 mediated hypokalaemia, and possible CYP3A4 inhibition.
What to do
Monitor ECG and correct potassium and magnesium in patients with other QT risk factors or on high-dose salbutamol. Watch for tremor and palpitations.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Salbutamol
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Salbutamol?
MediHelp rates the interaction as minor. Itraconazole and Salbutamol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs have been associated with QT prolongation, and salbutamol can lower potassium, which further raises the risk of torsades de pointes. Itraconazole may also modestly raise salbutamol exposure, although this is generally minor with inhaled doses.
How serious is the interaction between Itraconazole and Salbutamol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct potassium and magnesium in patients with other QT risk factors or on high-dose salbutamol. Watch for tremor and palpitations.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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