Drug interactions
Itraconazole + Triptorelin
Severity: Moderate
Itraconazole and Triptorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy such as triptorelin can prolong the QT interval, and itraconazole also has QT-prolonging potential. Combined use may raise arrhythmia risk, especially with other risk factors.
What this interaction means in plain words
Itraconazole and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Triptorelin belongs to Endocrine.
Why it happens
Additive effects on cardiac repolarization.
What to do
Check baseline ECG and electrolytes and monitor periodically in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Triptorelin
Frequently asked questions
Can I take Itraconazole with Triptorelin?
MediHelp rates the interaction as moderate. Itraconazole and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy such as triptorelin can prolong the QT interval, and itraconazole also has QT-prolonging potential. Combined use may raise arrhythmia risk, especially with other risk factors.
How serious is the interaction between Itraconazole and Triptorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes and monitor periodically in patients with cardiac risk factors.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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