Drug interactions
Itraconazole + Vinorelbine
Severity: Major
Itraconazole and Vinorelbine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may raise vinorelbine concentrations, increasing the risk of myelosuppression and neurotoxicity. The effect is expected from vinorelbine's CYP3A4-dependent metabolism.
What this interaction means in plain words
Itraconazole and Vinorelbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Itraconazole belongs to Anti Fungals; Vinorelbine belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated vinorelbine metabolism.
What to do
Avoid if possible; otherwise monitor blood counts and neuropathy and consider reducing the vinorelbine dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Vinorelbine
Frequently asked questions
Can I take Itraconazole with Vinorelbine?
MediHelp rates the interaction as major. Itraconazole and Vinorelbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole may raise vinorelbine concentrations, increasing the risk of myelosuppression and neurotoxicity. The effect is expected from vinorelbine's CYP3A4-dependent metabolism.
How serious is the interaction between Itraconazole and Vinorelbine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor blood counts and neuropathy and consider reducing the vinorelbine dose.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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