Drug interactions
Ivabradine + Lidocaine
Severity: Minor
Ivabradine and Lidocaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic lidocaine is a CYP3A4 substrate with little inhibitory effect, so a meaningful rise in ivabradine levels is unlikely. Both can affect cardiac conduction at high lidocaine doses.
What this interaction means in plain words
Ivabradine and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ivabradine belongs to Cardiovascular; Lidocaine belongs to Cardiovascular.
Why it happens
Weak theoretical CYP3A4 competition; no well-established mechanism.
What to do
No adjustment is needed for local anesthetic use; monitor heart rate and ECG during intravenous lidocaine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ivabradine
- Atazanavir + Ivabradine Contraindicated
- Clarithromycin + Ivabradine Contraindicated
- Cobicistat + Ivabradine Contraindicated
- Conivaptan + Ivabradine Contraindicated
- Darunavir + Ivabradine Contraindicated
- Diltiazem + Ivabradine Contraindicated
Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Frequently asked questions
Can I take Ivabradine with Lidocaine?
MediHelp rates the interaction as minor. Ivabradine and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic lidocaine is a CYP3A4 substrate with little inhibitory effect, so a meaningful rise in ivabradine levels is unlikely. Both can affect cardiac conduction at high lidocaine doses.
How serious is the interaction between Ivabradine and Lidocaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed for local anesthetic use; monitor heart rate and ECG during intravenous lidocaine.
What other medicines interact with Ivabradine?
MediHelp also lists interactions of Ivabradine with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Ivabradine page.
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