Drug interactions
Ivabradine + Timolol
Severity: Moderate
Ivabradine and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs slow heart rate, so together they increase the risk of bradycardia and conduction disturbances. The combination is common in heart failure and angina but requires attention to heart rate.
What this interaction means in plain words
Ivabradine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivabradine belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Additive heart rate lowering via sinoatrial If channel inhibition by ivabradine and beta-adrenergic blockade by timolol.
What to do
Monitor heart rate and symptoms of bradycardia, especially during initiation and dose titration. Reduce or stop ivabradine if resting heart rate falls too low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Other interactions of Ivabradine
- Atazanavir + Ivabradine Contraindicated
- Clarithromycin + Ivabradine Contraindicated
- Cobicistat + Ivabradine Contraindicated
- Conivaptan + Ivabradine Contraindicated
- Darunavir + Ivabradine Contraindicated
- Diltiazem + Ivabradine Contraindicated
Frequently asked questions
Can I take Ivabradine with Timolol?
MediHelp rates the interaction as moderate. Ivabradine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs slow heart rate, so together they increase the risk of bradycardia and conduction disturbances. The combination is common in heart failure and angina but requires attention to heart rate.
How serious is the interaction between Ivabradine and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and symptoms of bradycardia, especially during initiation and dose titration. Reduce or stop ivabradine if resting heart rate falls too low.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Timolol page.
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