Drug interactions
Ivacaftor + Lidocaine
Severity: Minor
Ivacaftor and Lidocaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor weakly inhibits CYP3A4 and P-glycoprotein, which could modestly increase lidocaine exposure. The effect is probably small at local anesthetic doses but may matter with systemic use or hepatic impairment.
What this interaction means in plain words
Ivacaftor and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ivacaftor belongs to Miscellaneous; Lidocaine belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP3A4 and P-glycoprotein by ivacaftor may reduce lidocaine clearance and efflux.
What to do
No routine adjustment is needed for local use. For systemic or high-dose lidocaine, monitor for CNS toxicity and cardiac conduction effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Ivacaftor with Lidocaine?
MediHelp rates the interaction as minor. Ivacaftor and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivacaftor weakly inhibits CYP3A4 and P-glycoprotein, which could modestly increase lidocaine exposure. The effect is probably small at local anesthetic doses but may matter with systemic use or hepatic impairment.
How serious is the interaction between Ivacaftor and Lidocaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed for local use. For systemic or high-dose lidocaine, monitor for CNS toxicity and cardiac conduction effects.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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