Drug interactions
Ivacaftor + Lorlatinib
Severity: Moderate
Ivacaftor and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor is a sensitive CYP3A4 substrate, and its exposure can drop markedly with CYP3A inducers. Lorlatinib may therefore reduce its efficacy in cystic fibrosis.
What this interaction means in plain words
Ivacaftor and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivacaftor belongs to Miscellaneous; Lorlatinib belongs to Oncology.
Why it happens
Lorlatinib induces CYP3A4, increasing ivacaftor metabolism.
What to do
Monitor respiratory function and clinical response to ivacaftor. Consider an alternative to lorlatinib if a loss of CFTR modulator effect is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Ivacaftor with Lorlatinib?
MediHelp rates the interaction as moderate. Ivacaftor and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivacaftor is a sensitive CYP3A4 substrate, and its exposure can drop markedly with CYP3A inducers. Lorlatinib may therefore reduce its efficacy in cystic fibrosis.
How serious is the interaction between Ivacaftor and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory function and clinical response to ivacaftor. Consider an alternative to lorlatinib if a loss of CFTR modulator effect is suspected.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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