Drug interactions
Ivacaftor + Morphine
Severity: Minor
Ivacaftor and Morphine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor can weakly inhibit P-glycoprotein, which may modestly raise morphine exposure. The effect is expected to be small, but opioid-related sedation and respiratory depression could be enhanced.
What this interaction means in plain words
Ivacaftor and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ivacaftor belongs to Miscellaneous; Morphine belongs to Musculoskeletal.
Why it happens
Weak inhibition of P-glycoprotein efflux transport by ivacaftor and its metabolite.
What to do
No routine dose change; monitor for increased sedation or respiratory depression and titrate morphine to effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Ivacaftor with Morphine?
MediHelp rates the interaction as minor. Ivacaftor and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivacaftor can weakly inhibit P-glycoprotein, which may modestly raise morphine exposure. The effect is expected to be small, but opioid-related sedation and respiratory depression could be enhanced.
How serious is the interaction between Ivacaftor and Morphine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change; monitor for increased sedation or respiratory depression and titrate morphine to effect.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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